Lifeline Cell Technology

In keeping with the theme of this week’s blog on the development of a high throughput preclinical airway model for testing anti-viral therapeutics against influenza and coronaviruses, we will be summarizing the final COVID-19 focus seminar published by the Journal of the American College of Cardiology. This seminar entitled Coronavirus and Cardiometabolic Syndrome outlines epidemiological/mechanistic…

A Pre-clinical Model to Evaluate Therapeutics for Respiratory Infections The current COVID-19 pandemic has highlighted the need for a robust pre-clinical model of the respiratory tract that can allow researchers to accurately and efficiently test potential therapeutic agents against emergent infections like SARS-CoV-2. Influenza and coronaviruses like SARS-CoV-2 utilize the lung and airway cells of…

A Better Drug Candidate to Treat Influenza Infections Influenza viruses are responsible for over 600,000 deaths globally and have a huge impact on human health and productivity. However, the moderate efficacy of influenza vaccines means that many individuals, particularly the elderly, still develop influenza infections even with vaccination. Current drug treatments for influenza infections include…

The Role of IL-22/PLCε Signaling in Psoriasis The outermost layer of the skin is the epidermis, which primarily functions as a protective mechanical barrier preventing the entry of harmful pathogens. The epidermis is predominantly composed of keratinocytes, but also contains other cell types like melanocytes, Langerhans cells, Merkel cells, and inflammatory cells. Psoriasis is a…