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Investigating Biomarkers for Early Detection of Ovarian Cancer

Female Reproductive Cells

 The Female Reproductive System The female reproductive system produces the female gametes, or germ cells, called eggs. Once fertilized by a sperm cell, the male gamete, the resultant zygote develops into a fetus during gestation. Human females are…

Smooth Muscle Cells: Researching New Therapies for Bladder Disorders

Smooth Muscle Cells

Bladder Anatomy and Function The bladder is responsible for collecting and storing the urine produced by the kidneys until it is voided from the body during urination. The inner epithelial layer of the bladder is called the urothelium…

Prostate Cancer and Development of Biomarkers

Male Reproductive Cells, Prostate Epithelial Cells

The prostate is a walnut-shaped male organ responsible for secreting prostatic fluid, which is an important component of seminal fluid. This year, the American Cancer Society estimates that 31,620 men will die from prostate cancer and approximately 171,650…

Research Using Lifeline® MSCs to Develop Therapies for Bone Defects

Mesenchymal Stem Cells

Multipotent, Pluripotent, and Totipotent Stem Cells and Induced Pluripotent Stem Cells Stem cells are undifferentiated cells that have two characteristics: they give rise to different mature cell types and have the ability to self-renew. However, not all stem…

Evaluating Chemotaxis of Epidermal Keratinocyte Migration

Keratinocytes

Keratinocytes: The Key Supporter of the Skin Barrier Keratinocytes are the most common cell type of the skin. They are present in the epidermis, which is the outermost layer of the skin, responsible for forming a barrier against…

Searching for Optimal Models for Endothelial Cell 3D Culture

Endothelial Cells

Endothelial Cells and the Extracellular Matrix (ECM) Endothelial cells line the vessels of the circulatory system and provide important support for vessel homeostasis, wound repair, and the inflammatory response. The ECM is a critical part of all tissues…

Lifeline®Research Products in Action: Half-Year Review 2019

Lifeline Cells and Media

Lifeline® Products in Research Studies in First Half of 2019 It’s that time again! Time for our mid-year review, where we look back on the last six months and review the variety of research being done using our…

Airway Epithelial Cells and Smoke Exposure in COPD Research

Lung/Airway Cells

Small Airway Epithelial Cells The airway is lined by a layer of epithelial cells with multiple functions. In addition to providing a protective barrier function, the airway epithelium also secretes mucus and is the primary target of respiratory…

Keratinocytes in Research: Epidermal Differentiation and Senescence

Keratinocytes

Function and Differentiation of Keratinocytes Keratinocytes make up the majority of cells in the epidermis, the outer layer of the skin. The progenitor cells that give rise to keratinocytes are found in the basal epidermal layer. As these…

The Metastatic Process in the Spread of Melanoma

Melanocytes and Keratinocytes

Melanoma: Causes and Prevention Melanoma is a type of skin cancer that arises from melanocytes, the pigmented cell type of the skin found in the outer layer of the skin (the epidermis). Although melanoma makes up only a…

3D Tissue Engineering for Studying Endometrial Dynamics

Female Reproductive Cells

Structure and Remodeling of the Endometrium The uterus is lined by a specialized tissue called the endometrium, which is composed of a layer of epithelial cells and underlying stromal cells. During the course of a woman’s menstrual cycle,…

Mitochondrial Function Studied Using Decompression Sickness Conditions

Fibroblasts

Fibroblast Function in Connective Tissue Fibroblasts are the most common cell type found in connective tissue throughout the body. Their main role is to produce the extracellular matrix and collagen fibers that support the connective tissue structure. In…

Endothelial Cells Studied for Potential Therapeutic Targets in Acute Respiratory Distress Syndrome (ARDS)

Endothelial Cells

Endothelial Cells and Maintenance of Barrier Integrity Endothelial cells form the innermost layer of the blood vessels and mediate important interactions with the blood. The endothelial layer is a monolayer that acts as a barrier between the blood…

Renal and Bladder Cancer Research Utilizing Lifeline Products as Normal Controls

Bladder Epithelial Cells, Renal Epithelial Cells

Lifeline® Renal and Bladder Cells as Normal Tissue Controls Cancer treatments are designed to selectively target cancer cells, while sparing the normal cells of the body. To design drugs with these properties, researchers must understand what makes cancer…

Introducing NEW Induced Pluripotent Stem Cell – Derived Neural Stem Cells

Neural Stem Cells

Stem cells are specialized cell types characterized by two properties: self-renewal and the ability to give rise to, or differentiate into, multiple cell types. Totipotent stem cells are located only in developing embryos and have the capacity to…

Toxic Antiseptic Agents and Searching for New Treatments for Psoriasis

Melanocytes and Keratinocytes

Anatomy of the Skin, the Body’s Largest Organ The skin is the largest organ in the human body and is the largest area in contact with the external environment. In addition to providing physical protection, the skin also…

Senescence of Airway Epithelial Cells in Asthma

Lung/Airway Cells

Lung and Airway Cells: First-Line Barriers to the Outside World Breathing air is something we do without thinking. But while we go about our day, our respiratory systems are hard at work extracting oxygen from the air and…

Considering Differences Between Hormone Stages in Research of the Female Reproductive Tract

Female Reproductive Cells

The Female Reproductive System Every month, the female reproductive system is responsible for the maturation and of an egg from one of the two ovaries. During this time, the inner lining of the uterus (or womb), called the…

Forward Motion Developing Liposomal Nanoparticle Delivery Systems

Endothelial Cells, Smooth Muscle Cells

Smooth Muscle Cells: Involuntary Contractile Cells Smooth muscle cells (SMCs) are spindle-shaped cells found throughout the body in the walls of many organs that have contractile function. For example, in the intestine, SMCs contract to push food and…

Quantifying the Effects of Hydrostatic Pressure and Homocysteine on Endothelial Cell Function

Endothelial Cells, Microvascular Endothelial Cells

Endothelial and Microvascular Endothelial Cells The cardiovascular system pumps blood to every tissue in our bodies through a network of arteries, veins, and capillaries. A key component of any blood vessel is a layer of endothelial cells, called…