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Herpes Simplex Virus, Nerve Damage; Melanoma, Tumor Pathogenesis

Keratinocytes

Anatomy of the Skin The skin is composed of three layers: epidermis, dermis, and hypodermis. The epidermis is the outermost layer of the skin and is primarily composed of keratinocytes, the cells from which basal cell carcinoma develop.…

Mesenchymal Stem Cells: Osteoarthritis, Cell Therapy and Tissue Engineering

Mesenchymal Stem Cells

Mesenchymal Stem Cells and Chondrogenic Differetiation Mesenchymal stem cells (MSCs) are multipotent cells found in certain tissues, such as the bone marrow and fat. They have the capacity to differentiate into certain cell types, including osteoblasts (bone cells),…

Coronary Artery Smooth Muscle Cells: Mediators of Vascular Remodeling

Cardiac Cells, Smooth Muscle Cells

Smooth Muscle Cells and Phenotypic Switching Smooth muscle cells (SMCs) are contractile cells found in various organs including the prostate, bladder, and uterus. In particular, SMCs that are located in the blood vessels of the cardiovascular system are…

Cardiac and Endothelial Cells: Promoting Vasculature Homeostasis

Cardiac Cells, Endothelial Cells

Endothelial and Cardiac Cells The cardiovascular system is operated by the heart and blood vessels, or vasculature. The heart is a muscular organ that provides the force to pump the blood throughout the body in a network of…

Prostate Smooth Muscle Cells and Prostate Fibroblasts Added to Lifeline Catalog

Fibroblasts, Smooth Muscle Cells

Prostate Cancer and the Search for New Biomarkers The prostate is part of the male reproductive system, responsible for making and secreting part of the seminal fluid, which supports the health and survival of semen. The secretory cells…

New Diseased Cell Additions to Lung and Airway Catalog

Lung/Airway Cells

The Airway: More Than Just Oxygen Exchange When air is inhaled, it travels through the airway to the lungs, where the oxygen is exchanged for carbon dioxide. A single layer of epithelial cells lines the airway, providing a…

Scleral Fibroblasts Added to Lifeline Catalog and Corneal Epithelial Cells in Action

Corneal Epithelial Cells

The Eye: Our Window to the World The eye is one of the major sensory organs, allowing us to see the world around us. When light hits the eye, it first encounters the cornea, the frontal dome-shaped part…

Melanocytes, Dermal Fibroblasts, and Keratinocytes – Protectors to the External World

Melanocytes and Keratinocytes

The Skin: A Multi-Cellular Barrier to the External World The skin is a multi-layered organ that covers the entire body and protects us from the external environment. The outermost layer, the epidermis, is largely composed of keratinocytes, which…

Smooth Muscle Cells: Key Regulators in Cardiovascular Disease

Lifeline Cells and Media, Smooth Muscle Cells

Smooth Muscle Cells: Regulators of Organ Contraction Smooth muscle cells (SMCs) are found in the walls of various organs, including the uterus, bladder, gastrointestinal tract, blood vessels, and more. They are the force behind the contraction of these…

Autophagy of Endothelial Cells Helping Maintain Homeostasis

Endothelial Cells

Large Vessel Endothelial Cells  Large vessel endothelial cells are found in arteries and veins and comprise the innermost layer of the vessel, forming a lining that separates the contents of the blood from the rest of the body.…

Arsenic Inhibition in Adipogenic Differentiation of Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal Stem Cells: Multipotent Progenitors of Bone, Fat, and Cartilage Mesenchymal stem cells (MSCs) are stem cells that can be found in the bone marrow, adipose tissue, and umbilical cord. These multipotent cells are capable of self-renewal, and…

Identifying New Biomarkers to Improve Diagnosis Using Prostate Epithelial Cells

Prostate Epithelial Cells

Prostate Cancer and Screening Prostate cancer is the second most common cancer type and second most common cause of cancer-related death in American men. Most prostate cancers are of epithelial origin, which means that the cells that become…

2018 Half-Year Review of Research with Lifeline® Products

Primary Cells

We’re halfway through 2018, which means it’s time for our bi-annual review. Every six months, we look back and review the research we have covered here on the blog, highlighting the different applications for which researchers have used…

Airway Epithelial Cells: Polarized Barrier Layer and the Latest Research

Lung/Airway Cells

Epithelial cells line many of the hollow organs in our bodies. A single layer of epithelium is composed of tightly packed individual epithelial cells that are connected to each other by protein complexes called tight junctions. Epithelia act…

Vascular Smooth Muscle Cells: Healing Wounds and Impacting Cardiovascular Health

Smooth Muscle Cells

Vascular Smooth Muscle Cells and Phenotype Switching Smooth muscle cells (SMCs) are specialized cell types found in the walls of many organs, including the stomach, small and large intestines, bladder, uterus, and blood vessels. In particular, the SMCs…

Keratinocytes and Dermal Fibroblasts: External Layers for Internal Protection

Melanocytes and Keratinocytes

The Multiple Layers and Cell Types of the Skin The skin is the ultimate barrier to the external environment, with a coverage area of the entire body. To perform its specialized functions, the skin is composed of multiple…

Endothelial Cells: Research in Cardiovascular Disease and Mesothelioma

Endothelial Cells

Endothelial Cells: Regulators of Vessel Homeostasis and Angiogenesis Endothelial cells line the blood vessels of the circulatory system and play major roles in cardiovascular homeostasis. Through extensive crosstalk with the circulating blood and various cell types contained in…

Determining the Role of JNK in Anoikis Using Mammary Epithelial Cells

Mammary Epithelial Cells

Mammary Gland Development The mammary gland is derived from the ectoderm, the outer layer of the embryo, and is formed into a series of ducts from which milk is produced. Although present at birth, the mammary gland undergoes…

Bladder Epithelial Cells: The Role of SETD6 on Bladder Cancer Growth and Survival

Bladder Epithelial Cells, Renal Epithelial Cells

The Excretory System: Waste Removal Experts Waste is removed from the body through an elegant filtration system that begins in the kidneys. The renal artery delivers blood to the kidneys, and in a series of filtration steps through…

Lifeline Cell Technology Adds Fallopian Tube Epithelial Cells to Catalog

Female Reproductive Cells

Now Available from Lifeline®: Fallopian Tube Epithelial Cells! The human female reproductive system is responsible for the development of eggs (the female gametes) the production of hormones (progesterone and estrogen), and importantly, supports development and delivery of a…