Brain illustration
Fibroblasts

Human iPSC-Derived Organoid Model to Study the Neuropathology of HIV-1

Human immunodeficiency virus (HIV) affects an estimated 38 million people worldwide with nearly 1.6 million new infections every year. Despite the availability of combined antiretroviral therapy (cART), a significant percentage of people with HIV will develop neurological deficits. The lack of suitable in vitro models that can accurately recapitulate the human brain has hindered the…
August 9, 2024 by Lifeline® Cell Technology
Wound Healing Blood
Fibroblasts

Effects of Hyperbaric Oxygen on Wound Healing

Fibroblasts have an important structural role in the body’s tissues, responsible for depositing the extracellular matrix (ECM) and collagen necessary for connective tissue support and tissue repair. In the context of skin injuries, dermal fibroblasts, which are the main cellular component of the skin, are critical in wound healing and function by contracting the wound…
June 25, 2021 by Lifeline® Cell Technology
skin irritation
Melanocytes and Keratinocytes

Mechanisms Driving Inflammation in Psoriasis

The Role of IL-22/PLCε Signaling in Psoriasis The outermost layer of the skin is the epidermis, which primarily functions as a protective mechanical barrier preventing the entry of harmful pathogens. The epidermis is predominantly composed of keratinocytes, but also contains other cell types like melanocytes, Langerhans cells, Merkel cells, and inflammatory cells. Psoriasis is a…
April 1, 2021 by Lifeline® Cell Technology
Gingival Fibroblasts image
Fibroblasts

Identifying a New Treatment for Periodontitis

Human Fibroblasts: Important Cells in Wound Healing and Inflammation Fibroblasts are the most common cell type comprising the connective tissue in humans and other mammals. These spindle-shaped cells synthesize extracellular matrix proteins that provide the structural framework, or stroma, for animal tissues. Besides their well-known structural role, fibroblasts are important in the wound healing response…
August 20, 2020 by Lifeline® Cell Technology
Human Fibroblast Cells
Fibroblasts

Mitochondrial Function Studied Using Decompression Sickness Conditions

Fibroblast Function in Connective Tissue Fibroblasts are the most common cell type found in connective tissue throughout the body. Their main role is to produce the extracellular matrix and collagen fibers that support the connective tissue structure. In addition to their role in maintaining connective tissue, fibroblasts are also key players in wound healing. Following…
May 9, 2019 by Lifeline® Cell Technology
DNA Cells
Lifeline Cells and Media

A Half-Year Review of the Latest Research with Lifeline® Multifunctional Cells

Halfway through 2017, here’s a recap of how researchers are using Lifeline® cells to study different disease mechanisms and biological processes. Lifeline® cells are being used to: engineer in vitro airway models, represent normal tissue controls for cancer studies, model capillary formation, and more. (We carry cells from 15 different tissue types and below are…
July 9, 2017 by Lifeline® Cell Technology
Woman with sunscreen on
Melanocytes and Keratinocytes

Making Strides in Skin Cell Research Utilizing Lifeline® Keratinocytes and Melanocytes

Cells of the Skin: Keratinocytes and Melanocytes The skin has three layers, the epidermis (outermost), the dermis (middle), and the hypodermis (the innermost). The epidermis is largely composed of keratinocytes, which form a barrier against the external environment and play a role in wound repair. Melanocytes are another common cell type found in the skin.…
June 11, 2017 by Lifeline® Cell Technology
Lifeline Normal Human Cells are Better Controls
Lifeline Cells and Media

Lifeline® Cells: Better Normal Controls for Therapeutic Development

Identifying the best cells to use as controls is critical. In particular, finding a “normal”, non-cancer control cell to test anti-cancer therapies is a challenge our customers often face. Lifeline® has the tools to help – read on to learn more. The phrase “normal cells” can sometimes be misleading. In fact, “normal” immortalized cell lines…
April 13, 2017 by Lifeline® Cell Technology