endothelial cells as regulators of blood vessel homeostatis
Endothelial Cells

Endothelial Cells: Regulators of Blood Vessel Homeostasis

Endothelial cells line the blood vessels of the body and participate in significant crosstalk with the blood and tissues to maintain blood pressure and vessel homeostasis through regulation of vasodilation and vasoconstriction. In particular, endothelial cells have been implicated in atherosclerosis, a significant health issue and risk factor for heart attackand stroke. Atherosclerosis is characterized…
June 25, 2017 by Lifeline® Cell Technology
Human Endothelial Cells as Barriers
Endothelial Cells

Endothelial Cells as Blood Vessel Barriers — The Latest Research Studies

Endothelial cells form a monolayer that lines the lumen of blood vessels, provides an essential protective barrier, and regulates vessel and blood pressure homeostasis. Endothelial cells are also involved in forming new blood vessels, a process called angiogenesis. During cancer cell metastasis, cancer cells break off from a primary tumor and travel through the bloodstream…
March 5, 2017 by Lifeline® Cell Technology
cardiovascular system diagram
Endothelial Cells

Endothelial Cells: Cardiovascular Multi-Taskers in the Latest Studies

The cardiovascular system is an extensive network that supports blood flow to the tissues of the body. Blood vessels have a specialized lining of endothelial cells that not only regulate vessel homeostasis, but also form a protective barrier between factors in the blood and the internal environment. They have substantial migratory ability and also participate…
November 11, 2016 by Lifeline® Cell Technology
Skin cells on a woman's face
Melanocytes and Keratinocytes

Epidermal Cells – Our First Line of Defense — and Recent Studies

The skin is a multi-layered organ that covers the entire body and serves as a barrier to the outside environment. The outermost layer is called the epidermis and is composed largely of keratinocytes, which function to provide a barrier to pathogens, temperature, UV radiation, and other damaging environmental factors. Also contained in the epidermis are…
November 16, 2015 by Lifeline® Cell Technology

VascuLife® VEGF-Mv Endothelial Complete Kit

VascuLife® VEGF-Mv (containing Vascular Endothelial Growth Factor) is a medium optimized for the culture of Primary Human Microvascular Endothelial Cells. VascuLife supports the rapid proliferation of these cells in a 5% serum environment. Primary Microvascular Endothelial Cells cultured in VascuLife Microvascular medium medium out-perform Primary Cells grown in any similar medium.  You’ll get consistently reproducible…
September 1, 2015 by Lifeline® Cell Technology

VascuLife® EnGS-Mv Microvascular Endothelial Kit

VascuLife® EnGS-Mv Medium (containing Endothelial Cell Growth Supplement) is optimized for the culture of Human Primary Microvascular Endothelial Cells. VascuLife culture medium supports the rapid proliferation of these Primary Microvascular Endothelial Cells in a 5% serum environment. Primary Microvascular Cells cultured in VascuLife medium out-perform Primary Cells grown in any similar medium.  You’ll get consistently…
September 1, 2015 by Lifeline® Cell Technology
Pulmonary Artery Endothelial Cells 10x FC-0055
Endothelial Cells

Endothelial Cells: the Good, the Bad, and the Source

The Good: Endothelial cells make up the inner lining of blood and lymphatic vessels. Vascular endothelial cells specifically line the entire circulatory system including small blood vessels (microvascular), large blood vessels (macrovascular), and the heart. Here is a short list of their important functions in the human body: Control blood pressure by modulating vascular tone Prevent…
April 20, 2015 by Lifeline® Cell Technology
Scientist with test tubes
Lifeline Cells and Media

Enabling Research Success with Optimized Primary Cell Culture Media

Obtaining high-quality primary cells is only half the equation for experimental success. Equally important is the use of optimized cell culture media that can preserve the biological and functional integrity of those cells in vitro. Unlike immortalized cell lines, primary cells have a limited lifespan in culture and are more sensitive to suboptimal conditions, making…
June 13, 2025 by Lifeline® Cell Technology
Atherosclerosis
Cardiac Cells

Breast Cancer Drug Neratinib Found to Protect Against Atherosclerosis

American Heart Month Atherosclerosis is a common disease that develops when the buildup of fats, cholesterol and other substances in and on the artery walls. This buildup—called plaque—can cause arteries to narrow, blocking blood flow or even burst, resulting in a blood clot. Heart diseases linked to atherosclerosis, or atherosclerotic cardiovascular disease (ASCVD), remains the…
February 13, 2025 by Lifeline® Cell Technology
Skin
Epithelial Cells, Keratinocytes, Primary Cells

The Role of Hedgehog Receptors in Regulating the Epidermal Immune Response

National Healthy Skin Month emphasizes the importance of maintaining healthy skin as a key aspect of overall health and well-being. The skin barrier, specifically the epidermis, protects the body against environmental threats, such as pathogens and chemicals, while also helping to maintain internal homeostasis and preventing water loss from the body. Improving our understanding of…
November 12, 2024 by Lifeline® Cell Technology
Brain illustration
Fibroblasts

Human iPSC-Derived Organoid Model to Study the Neuropathology of HIV-1

Human immunodeficiency virus (HIV) affects an estimated 38 million people worldwide with nearly 1.6 million new infections every year. Despite the availability of combined antiretroviral therapy (cART), a significant percentage of people with HIV will develop neurological deficits. The lack of suitable in vitro models that can accurately recapitulate the human brain has hindered the…
August 9, 2024 by Lifeline® Cell Technology
Man smoking outside
Cardiac Cells

Strategies for Cardiovascular Risk Reduction in Smokers

For American Heart Month, we want to highlight the importance of advancing cardiovascular research to better understand vascular health, heart function, disease mechanisms, and to develop new therapies for disease treatment. Cardiovascular disease (CVD) remains the leading cause of death in the United States, claiming the lives of approximately 695,000 Americans in 2021 alone. Cigarette…
February 21, 2024 by Lifeline® Cell Technology
stethoscope heart blog
Endothelial Cells

Impact of E-Cigarette Smoke on Cardiovascular Function

Cigarette smoking is one of the primary risk factors for cardiovascular disease (CVD). In fact, the American Heart Association reports that smoking-related diseases are responsible for > 440,000 deaths in the US each year. Cigarette smoke contains hundreds of chemical toxicants, which can damage the cardiovascular system, and increase the risk of developing atherosclerosis. Atherosclerosis…
November 4, 2021 by Lifeline® Cell Technology