The excretory system processes the body’s waste and excretes waste as urine. The two kidneys filter waste products from the blood, creating urine. The urine is then passed from the kidney to ureters, finally reaching the bladder from where urine is excreted. Renal cancer and bladder cancer are both initiated in kidney (renal) and bladder epithelial cells, respectively.
Lifeline® provides both bladder and renal epithelial cells for your research needs.
- Bladder epithelial cell types include bladder dome epithelial and apex bladder epithelial cells, isolated from different areas of the bladder and optimized for growth in UroLife™
- Renal epithelial cells offered by Lifeline® and optimized for growth in RenaLife™ medium include: renal medullary epithelial cells, renal proximal tubule epithelial cells, and renal cortical epithelial cells.
Both renal and bladder epithelial cells can be used for multiple research applications. Studies using these cells for such applications are listed below.
Studies Using Lifeline® Bladder and Renal Cells for Research Applications
Studies that investigated the anti-tumor activity of a new peptide or a new combination of chemotherapeutic agents in cancer cell lines versus Lifeline® normal human bladder cells:
CLT1 Targets Bladder Cancer through Integrin α5β1 and CLIC3
CLT1 targets angiogenic endothelium through CLIC1 and fibronectin
Simultaneous Targeting of Bladder Tumor Growth, Survival, and Epithelial-to-mesenchymal Transition with a Novel Therapeutic Combination of Acetazolamide (AZ) and Sulforaphane (SFN)
Studies that examined the cytotoxicity of natural or synthetic compounds in renal cancer cell lines compared to Lifeline® normal human renal epithelial cells:
Englerin A Selectively Induces Necrosis in Human Renal Cancer Cells
Heterometallic Titanium-gold Complexes Inhibit Renal Cancer Cells In Vitro and In Vivo
Studies that investigated cell cycle arrest or induction of apoptosis in cancer cell lines versus Lifeline®normal human bladder or normal human renal epithelial cells:
Silencing of ATPase Inhibitory Factor 1 Inhibits Cell Growth via Cell Cycle Arrest in Bladder Cancer
Withanolide E Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis by Increasing of cFLIP Degradation
Studies that used Lifeline® normal human renal epithelial cells to study protection from kidney damage or regeneration of tissue after kidney damage:
L-Citrulline Protects from Kidney Damage in Type 1 Diabetic Mice
Distinct bone morphogenetic proteins activate indistinguishable transcriptional responses in nephron epithelia including Notch target genes
We are always interested in learning how you are using Lifeline® cells in your research. Share your study with us and your group could be featured here on our blog!