Face made out of bricks
Melanocytes and Keratinocytes

Melanocytes, Dermal Fibroblasts, and Keratinocytes – Protectors to the External World

The Skin: A Multi-Cellular Barrier to the External World The skin is a multi-layered organ that covers the entire body and protects us from the external environment. The outermost layer, the epidermis, is largely composed of keratinocytes, which proliferate in the lower epidermis and migrate out, becoming post-mitotic and losing their nuclei, eventually becoming corneocytes.…
August 31, 2018 by Lifeline® Cell Technology
Human Fibroblasts
Fibroblasts

Lifeline® Dermal Fibroblasts Utilized in Wound Healing Study

Fibroblasts: Important Players in Wound Healing Fibroblasts are a mesenchymal cell type, known for their spindle shape. Although they are present in most tissue types, they are often found in connective tissue due their function in producing extracellular matrix proteins. While they normally function to maintain homeostasis through extracellular matrix maintenance, they have a particularly…
May 28, 2017 by Lifeline® Cell Technology
dermal fibroblasts
Fibroblasts

Dermal Fibroblasts Used to Study Induced Pluripotent Stem Cells and UV Radiation

The skin is the body’s first level of defense against the external environment. It is composed of multiple tissue layers that are held together by connective tissue, which supports and maintains the tissue, and contains immune system components. Connective tissue in the skin is generated by dermal fibroblasts—specialized cells located in the dermis, the second…
January 10, 2016 by Lifeline® Cell Technology
FC-0001, Neonatal Fibroblasts, 10x v2

Human Dermal Fibroblasts – Neonatal, Primary

Lifeline® Primary Normal Human Skin Fibroblasts – Neonatal (HDFn) provide an ideal cell system to establish serum free human feeder layers for human embryonic stem cell cultures or as a model to study wound healing, toxicology or basic cell biology. Primary Dermal Neonatal Fibroblasts are isolated from neonatal human foreskin and cryopreserved after primary culture…
September 8, 2015 by Lifeline® Cell Technology
Scleral Fibroblasts
Fibroblasts

Dental Implant Biomaterial and Myopia Research Using Lifeline’s Fibroblasts

Gingival and Scleral Fibroblasts Fibroblasts are a spindle-shaped cell present in the connective tissue of the body. Their main function is to produce elements of the extracellular matrix, a tissue support network composed of collagen, glycoproteins, and elastin. Human gingival fibroblasts are located in the periodontal tissue, or gums, in the mouth. They help to…
March 5, 2020 by Lifeline® Cell Technology
Stromal cells
Fibroblasts

Fibroblasts Studies: The Mitochondria and the Cytoskeleton, and Treating Yeast Biofilms

Fibroblasts are the main cell type in stromal tissue, the supporting tissue of an organ that contains structural and connective components. They are a multifunctional cell type whose main function is to secrete extracellular matrix, which forms the connective tissue of an organ. Fibroblasts play important roles in tissue homeostasis, and fibroblast dysregulation can play…
January 19, 2018 by Lifeline® Cell Technology
human fibroblasts
Fibroblasts

Human Fibroblasts: a Multi-Faceted Cell Type

Fibroblasts are a type of mesenchymal cell most commonly found in the connective tissue of many organs, including the gastrointestinal tract, skin, bladder, uterus, and others. Fibroblasts produce connective tissue and extracellular matrix, both of which are important for supporting the organs in which they are produced. In addition, fibroblasts crosstalk extensively with surrounding tissues,…
August 18, 2016 by Lifeline® Cell Technology
Skin cells on a woman's face
Melanocytes and Keratinocytes

Epidermal Cells – Our First Line of Defense — and Recent Studies

The skin is a multi-layered organ that covers the entire body and serves as a barrier to the outside environment. The outermost layer is called the epidermis and is composed largely of keratinocytes, which function to provide a barrier to pathogens, temperature, UV radiation, and other damaging environmental factors. Also contained in the epidermis are…
November 16, 2015 by Lifeline® Cell Technology
Researcher looks at cells under a microscope
Fibroblasts

Fibroblasts: Oh, the Places You Will Go . . .

What are Fibroblasts? Fibroblasts are connective tissue cells that secrete the components that make up the extracellular matrix and the stroma. Both these structures provide a supportiv framework that keeps cells, tissues, and organs in their proper places. There are many different types of fibroblasts located in organs and tissues throughout the body. The main structural protein secreted by…
July 11, 2015 by Lifeline® Cell Technology

iPS Validated Fibroblasts

iPS Validated Fibroblast Cell Culture Systems Lifeline® Normal Human Dermal Fibroblasts have been validated for their ability to become Induced Pluripotent Stem Cells (iPS). Neonatal Fibroblast cells, LOT#00866, can be transduced with lentiviral vectors with very high efficiencies. Normal Human Dermal Fibroblasts derived from neonatal skin are cryopreserved as primary cells to ensure the highest…
June 18, 2015 by Lifeline® Cell Technology
Wound Healing Blood
Fibroblasts

Effects of Hyperbaric Oxygen on Wound Healing

Fibroblasts have an important structural role in the body’s tissues, responsible for depositing the extracellular matrix (ECM) and collagen necessary for connective tissue support and tissue repair. In the context of skin injuries, dermal fibroblasts, which are the main cellular component of the skin, are critical in wound healing and function by contracting the wound…
June 25, 2021 by Lifeline® Cell Technology
skin irritation
Melanocytes and Keratinocytes

Mechanisms Driving Inflammation in Psoriasis

The Role of IL-22/PLCε Signaling in Psoriasis The outermost layer of the skin is the epidermis, which primarily functions as a protective mechanical barrier preventing the entry of harmful pathogens. The epidermis is predominantly composed of keratinocytes, but also contains other cell types like melanocytes, Langerhans cells, Merkel cells, and inflammatory cells. Psoriasis is a…
April 1, 2021 by Lifeline® Cell Technology